The current opioid epidemic warrants a better understanding of genetic and environmental factors that contribute to opioid addiction. Here we report an increased prevalence of vitamin D (VitD) deficiency in patients diagnosed with opioid use disorder and an inverse and dose-dependent association of VitD levels with self-reported opioid use. We used multiple pharmacologic approaches and genetic mouse models and found that deficiencies in VitD signaling amplify exogenous opioid responses that are normalized upon restoration of VitD signaling. Similarly, physiologic endogenous opioid analgesia and reward responses triggered by ultraviolet (UV) radiation are repressed by VitD signaling, suggesting that a feedback loop exists whereby VitD deficiency produces increased UV/endorphin-seeking behavior until VitD levels are restored by cutaneous VitD synthesis. This feedback may carry the evolutionary advantage of maximizing VitD synthesis. However, unlike UV exposure, exogenous opioid use is no
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Sentara Healthcare and Cone Health represent the latest in a series of scuttled merger proposals, but it isn t expected to slow M&A activity, industry observers said.
Sentara and Cone abandoned their plans Wednesday to build a more than $11 billion system spanning North Carolina to Virginia amidst internal opposition as well as criticism from community members and state regulators. Around a dozen proposed mergers between relatively healthy not-for-profit systems haven t closed over the past three years as doctors have protested and regulators have become increasingly wary of consolidation. I do think it s reflective of this new attitude toward consolidation in healthcare where more than ever, enforcers are suspicious of systems that are growing and skeptical of the benefits they claim they ll bring, said Ken Field, an attorney with Jones Day who works on healthcare antitrust and competition issues. It s almost as if we re starting from a position of disapproval as
/Global Telemedicine And M-Health Convergence Market Share is Expected To Get Massive Profits by 2027 – Market Research Store Trending
Global Telemedicine And M-Health Convergence Market Share is Expected To Get Massive Profits by 2027 – Market Research Store
richardMay 26, 2021 5
Global Telemedicine And M-Health Convergence Market Key Players, Business Approaches And Geographical Analysis Amid COVID-19 Pandemic
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Marc Willard Joins Validic Board of Directors
Former Senior Vice President of Digital Health and Analytics at Humana brings deep Payer, Tech and Provider expertise to Validic s Board of Directors, extending reach into key markets
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DURHAM, N.C., May 26, 2021 /PRNewswire/
Validic®, provider of the industry s premier platform and solutions to orchestrate personal health data, today announced that former Humana executive Marc Willard has joined Validic s Board of Directors. Willard s background includes three decades of experience founding healthcare technology companies and leading digital transformation for health plans and health systems. Willard s appointment informs how Validic is further developing its strategy and offerings for the next wave of leading health insurers and systems.
May 25, 2021
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David Thomas ’78 B.A., ’86 Ph.D.
Distinguished scholar and Morehouse College president David Thomas ’78 B.A., ’84 M.A., ’84 M.PHIL., ’86 Ph.D. has been elected to serve as an alumni fellow of Yale’s Board of Trustees, known formally as the Yale Corporation, in worldwide balloting of university graduates. He begins a six-year term on July 1.
Before being appointed president of Morehouse College, in Atlanta, in 2018, Thomas served as dean and William R. Berkley Chair of the Georgetown University McDonough School of Business from 2011 to 2017; as the H. Naylor Fitzhugh Professor of Business Administration at Harvard University from 1990 to 2011; and as assistant professor of management at the University of Pennsylvania’s Wharton School from 1986 to 1990. His scholarly work focuses on the intersection of race, careers, and organizations.