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Gene Transcription Fine Tuned by New Checkpoint Mechanism Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute] May 18, 2021 Alessandro Gardini, Ph.D., assistant professor in the Gene Expression & Regulation Program at The Wistar Institute, in his lab. [Wistar Institute] Share Researchers from the Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, say they have discovered a new checkpoint mechanism that fine-tunes gene transcription. Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII).

United statesRicky johnstoneAlessandro gardiniCancer researchGene expression regulation programSir peter maccallum department of oncologyUniversity of melbournePeter maccallum cancer centrePeter maccallum cancer centerWistar instituteGene expressionRegulation programSir peter maccallum departmentProtein phosphataseஒன்றுபட்டது மாநிலங்களில்புற்றுநோய் ஆராய்ச்சி