Following is a transcript of their remarks:
Vinay Prasad, MD: I m back with Aaron Goodman and Al-Ola Abdallah, and we re talking about ASH abstracts. Gentlemen, the myeloma field is excited about CAR-T or cellular therapy and they are going after all sorts of targets. Of course, they start with BCMA [B-cell maturation antigen], but they ve expanded from there, and CAR-T therapies are incredibly exciting.
Those of us who ve used them in lymphoma, who have seen the ability to take a chemo-resistant patient and render them free of disease, folks who have used them in pediatric ALL [acute lymphocytic leukemia] have seen the impressive powers of CAR-T. It is not an easy therapy to administer. Often side effects are profound, including neurotoxicity.
Following is a transcript of their remarks:
Vinay Prasad, MD: I m back with Dr. Aaron Goodman and Dr. Al-Ola Abdallah and we re talking about ASH and multiple myeloma. We have an exciting study to discuss, the FORTE study. This is a three-arm study that looks at carfilzomib-containing regimens, which, to my knowledge, is not the official standard of care in multiple myeloma in the frontline setting, although some believe it plays a role, and they ask a very provocative question about the role of transplant and maintenance.
Dr. Goodman, I wonder if you might summarize the FORTE study. What is going on in FORTE, what are we finding, and what should we be thinking about?
Following is a transcript of their remarks:
Hope Rugo, MD: Hello and welcome to this virtual roundtable where we will be discussing some of the key data that emerged from this year s San Antonio Breast Cancer meeting. I m Hope Rugo, professor of medicine at the University of California San Francisco s Comprehensive Cancer Center, and I m joined today by two expert leaders in the field of breast cancer and great colleagues, Dr. Jennifer Litton from the MD Anderson Cancer Center and Dr. Jo Chien from the University of California San Francisco s Comprehensive Cancer Center. Thanks for joining me today.
Now, we re going to talk about a really interesting set of presentations at San Antonio that I think really do have direct implications for clinical practice on Monday and this is the use of genomic tests and in some of the studies, Ki67 in order to try and inform us about how to treat our patients who have higher risk node-positive disease.
Following is a transcript of their remarks:
Susan O Brien, MD: Hi, everyone, and welcome to this roundtable where we re going to discuss CLL presentations at ASH 2020 this year. I m Dr. Susan O Brien from the Chao Family Comprehensive Cancer Center at the University of California in Irvine, and I m joined by two esteemed colleagues, Dr. Jennifer Brown from Dana-Farber and Dr. Anthony Mato from Memorial Sloan Kettering.
We have two presentations today on the TRANSCEND clinical trial, and that is an interesting CAR-T trial of liso-cel which targets CD19, like many of the other CAR-Ts, but is a little bit different in that it has a defined component of CD4 and CD8 cells, which I think is the only CAR-T that s actually doing that. One of the presentations involved just the CAR-T alone and the other was the CAR-T given in combination with ibrutinib. Jennifer, maybe you could speak to that and the rationale for actually giving it with ibrutinib in the sense that many of the patients had
Following is a transcript of their remarks:
Hope Rugo, MD: Hello and welcome to this virtual roundtable where we will be discussing some of the key data that emerged from this year s San Antonio Breast Cancer meeting. I m Hope Rugo, professor of medicine at the University of California San Francisco s Comprehensive Cancer Center, and I m joined today by two expert leaders in the field of breast cancer and great colleagues, Dr. Jennifer Litton from the MD Anderson Cancer Center and Dr. Jo Chien from the University of California San Francisco s Comprehensive Cancer Center. Thanks for joining me today.
Now I think what we ll do is focus on novel therapy, some of the novel therapies that were presented at San Antonio. We can t be exhaustive, of course, but we ll talk about some of the agents that either are already being used in the clinic or are emerging agents. One area of great interest is oral taxanes. We ve been trying to get oral taxanes for ages. There is a problem with absorpti