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New Genetic Link to Male Infertility Identified by Hannah Joy on  April 5, 2021 at 10:18 PM Men who have the unstable Y chromosome are at higher risk of genomic rearrangements, which affect the sperm production process (spermatogenesis). This, in turn, makes men nine times more likely to have fertility issues, reveals a new study published in eLife. Molecular diagnostics of this genetic variant could help identify those at higher risk in their early adulthood, giving them the chance to make decisions about future family planning early on. Currently, the exact cause of infertility remains unknown in more than half of men with spermatogenic impairment.

Czech republicUnited kingdomPille hallastChris tyler smithMargus punabMaris laanAndrology centre of tartu university hospitalWellcome sanger instituteHuman genetics research groupTartu instituteTranslational medicineAndrology centreTartu university hospitalProfessor margusHuman geneticsTartu maris laan