Phase 3 DREAM3R trial opens for malignant pleural mesothelioma
The DREAM3R phase three clinical trial is now enrolling patients with newly diagnosed unresectable malignant pleural mesothelioma (MPM) throughout the US, Australia, and New Zealand. The DREAM3R study builds on signals of effectiveness found in independent single-arm phase two trials, PrE0505 and DREAM. These trials evaluated durvalumab immunotherapy during and after standard chemotherapy.
DREAM3R will determine if concurrent chemo-immunotherapy can improve outcomes in malignant pleural mesothelioma, especially for the majority of patients with the epithelioid subtype. Both the DREAM and PrE0505 phase 2 trials showed remarkable results in MPM with the combination of chemotherapy and durvalumab, and warrant confirmation in a randomized phase 3 trial.
KATY, Texas – At 83-years-old, James Thomas Jones was a beloved father, grandfather and great grandfather.
He was a former technician who worked in the oil industry and a man who battled COPD, a serious lung ailment that required for him to breathe with the help of an electric respirator.
During Houston’s historic winter storm last month, the Katy home that James lived in with his daughter and son-in-law lost power and later Jones eventually died.
“CenterPoint Energy did not plan properly for this power outage, and CenterPoint did not care,” said Benny Agosto Jr., attorney for Jones’ family.
“They had the control and the ability to control the distribution of power over our area and they did not do that, and because of that Mr. Jones is no longer with us,” Agosto Jr. said.
Not much help for special needs Texans who need electricity to live - so what is next?
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HOUSTON – We know a lot of you lost power during the February winter storm. But for many, it was a really dangerous time. For those who rely on machines to live, losing electricity can be an emergency situation. We found out, a tool that is supposed to help didn’t do much.
The Taylor family from Katy, like so many others in our community, lost power last month.
“Even though we thought we were prepared in an emergency, we quickly realized that because we were without power for 48 hours, that created a major problem,” said Lora Taylor. “We kind of went into overdrive prayed a lot.”
Scientists discover how novel pathogens promote colorectal cancer development
Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote cancer development in the long term. BMMFs and inflammatory markers were significantly more frequently detectable in the vicinity of malignant intestinal tumors than in the intestinal tissue of tumor-free individuals.
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