Apr 9, 2021
Available evidence does not support causal inference
Clinical details of a participant in a Covid-19 vaccine trial who developed Guillain-Barré syndrome (GBS) after vaccination were published in
Two cases of GBS, one in the active and one in the placebo arm, were reported in the Ad26.COV2.S (Johnson & Johnson) Covid-19 vaccine trial data. “Our patient in the vaccine arm did not have any clinical features differentiating her from patients with typical GBS,” wrote Anthony Amato, MD, and co-authors, all of Brigham and Women’s Hospital, Boston.
“From the available evidence, it is not possible to draw causal inferences about the association of Covid-19 vaccination and the development of GBS,” they added.
email article
The TransMedics Organ Care System (OCS) Heart System got closer to regulatory approval as it emerged victorious from a contentious FDA advisory committee meeting.
Members of the agency s Circulatory System Devices Panel voted 12-5 (with one abstention) that the OCS Heart System s benefits outweigh its risks as a device that could potentially widen the pool of donor hearts perhaps even reduce waitlist times by preserving non-standard donor hearts longer than traditional cold storage during transport.
Panelists voting in favor did so despite complaining of flimsy safety and effectiveness data in the PROCEED II, EXPAND, and EXPAND CAP studies.
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Increased physical activity attenuated
APOE ε4-related vulnerability to early cognitive decline in Parkinson’s disease (PD) patients, a retrospective cohort study found.
“This study provides Class II evidence that increased physical activity was associated with decreased
APOE ε4-related early cognitive decline in PD patients,” wrote Jin-Sun Jun, MD, of Hallym University in Seoul, Korea, and co-authors in
“This protective effect did not appear to be mediated by striatal dopaminergic function,” they added.
Jun and colleagues analyzed data from the Parkinson’s Progression Markers Initiative. All 173 patients (baseline mean age: 63 years) were recently diagnosed with idiopathic PD and had abnormal dopamine transporter (DAT) imaging while untreated. In all, 27% were
Mysterious Ailment, Mysterious Relief: Vaccines Help Some COVID Long-Haulers nhpr.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nhpr.org Daily Mail and Mail on Sunday newspapers.