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Noninvasive probe monitors health of friendly gut bacteria

Noninvasive probe monitors health of friendly gut bacteria Written by James Kingsland on February 17, 2021 Fact checked by Hannah Flynn, MS Photography courtesy of Nicola Fawcett/Wikimedia The community of bacteria that live in the gut, known as the gut microbiota, play a pivotal role in illnesses such as cancer, diabetes, obesity, depression, and inflammatory bowel disease. The aim of probiotic and prebiotic supplements is to restore a healthy balance to the microbiome, but their effects are difficult to study. Researchers have developed a probe that can measure the activity level of an enzyme produced by bacteria that is key to their health-promoting effects.

Researchers develop a non-invasive diagnostic tool for developing personalized probiotics, prebiotics

Researchers develop a non-invasive diagnostic tool for developing personalized probiotics, prebiotics
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Bioluminescent imaging capsule captures probiotic efficacy

Researchers have harnessed the power of bioluminescent imaging to better assess the health benefits of prebiotics and probiotics via a capsule that measures enzyme activity. By measuring levels of bile salt hydrolase in the gastrointestinal tract, the US-based team thinks that assessments can be accurately made about how severe inflammatory bowel diseases are. In addition, the capsule could determine the efficacy of many commercially available probiotic supplements by testing levels of the enzyme, thought to be responsible for probiotic health benefits. The team also think that the swallowable capsule could evaluate whether certain types of prebiotics can increase bile salt hydrolase levels in a similar way that probiotic supplements do.

Gut-testing capsule indicates benefits to prebiotics

A new noninvasive diagnostic imaging tool measures the levels of a naturally occurring enzyme bile salt hydrolase inside the body’s entire gastrointestinal tract, research finds. Inside the human body lives a large microscopic community called the microbiome, where trillions of bacteria engage in a constant “tug of war” to maintain optimal levels of good and bad bacteria. Most of this struggle takes place within the body’s gastrointestinal tract, as bacteria help with digesting food and support the immune system. Although health experts believe good “gut” health is key to a person’s health and well-being, scientists are still developing a detailed picture of what goes on inside a person’s gastrointestinal tract.

Probiotics or prebiotics? Exploring the complex world of gut health

 E-Mail IMAGE: An illustration of the non-invasive way for identifying the major functions of the gastrointestinal tract. view more  Credit: Illustration is courtesy of Marina Resnyanskaya. A healthy person has a general balance of good and bad bacteria. But that balance is thrown off when someone gets sick. So, to help boost their levels of good bacteria, many people take probiotic supplements live bacteria inside of a pill. Various commercial probiotic supplements are available for consumer purchase, and while health experts generally agree about their overall safety, controversy surrounds their efficacy. Inside the human body lives a large microscopic community called the microbiome, where trillions of bacteria engage in a constant tug of war to maintain optimal levels of good and bad bacteria. Most of this struggle takes place within the body s gastrointestinal tract, as bacteria help with digesting food and support the immune system. Although health experts b

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