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In 1994, a World Health Organization (WHO) study group published an attempt at predicting the risk of fragility fractures based on bone mineral density (BMD). Before this report, the diagnosis of osteoporosis was clinical that is, following the occurrence of a low-impact (fragility) fracture, and, depending on clinical sagacity, other related factors that can be discovered in the personal history.
While the science and technical capacity of dual-energy x-ray absorptiometry (DXA) were comparatively primitive at the time, early machines had been introduced into clinical use and this diagnostic capacity was probably the inspiration for this BMD-based effort. Expressed in simple terms, the devices measured the attenuation of a modulated x-ray beam per cm
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Women with obesity may have a higher risk of heavier periods due to delayed endometrial repair. Although it is difficult to make strong recommendations based on this study alone, a common-sense approach would be to offer weight-loss support to women with a high BMI experiencing heavy periods, suggested lead author Jacqueline Maybin, MBChB, PhD, of the University of Edinburgh, in a statement. (
Journal of Endocrinology)
A new subgroup analysis of the phase III SONICS trial found that levoketoconazole (Recorlev) was effective at normalizing mean 24-h urinary free cortisol in people with Cushing s and improved glycemic control in those with comorbid diabetes. (
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New approach predicts risk of bone fractures in elderly men
Fractures in the vertebrae of the spine and calcification in a blood vessel called the abdominal aorta can both be visualized through the same spinal imaging test.
A new study published in the
Journal of Bone and Mineral Research that included 5,365 older men indicates that each of these measures are linked with a higher risk of developing hip and other fractures.
Investigators found that including both measures compared with including only abdominal aortic calcification or only vertebral fractures improved the ability to predict which men were most likely to experience a hip or other fracture in the future.