Smurf2-deficient mice.
In the
Smurf2-deficient mice, ectopic bone induced by bone morphogenetic protein (BMP) was large and composed of abundant trabecular bone.. view more
Credit:
Bone Research (Springer Nature) ISSN 2095-6231 (online)
Osaka, Japan - Bone morphogenetic protein (BMP) has a strong osteogenic (bone forming) ability. BMP has already been clinically applied to spinal fusion and non-union fractures. However, dose-dependent side effects related to BMP use, such as inflammatory reactions at the administration site, prevent widespread use.
For safe use, it was necessary to clarify how the BMP signaling pathway is controlled. In a report published in
Bone Research, a group of researchers from Osaka University and Ehime University has recently identified a novel role for the protein Smurf2 in regulating bone formation by BMP.
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CHARLOTTESVILLE, VA (FEBRUARY 2, 2021). Researchers in the United Kingdom (UK) conducted a randomized controlled trial in 47 patients with lumbar spinal stenosis to compare treatment outcomes and costs of two competing surgical procedures: insertion of the X-Stop® (Medtronic) interspinous distractor device and open decompression surgery with laminectomy. Both procedures improved the patients quality of life; however, overall, laminectomy gave patients a better quality of life and was also more cost-effective.
Detailed findings of this study can be found in a new article, A randomized controlled trial of the X-Stop interspinous distractor device versus laminectomy for lumbar spinal stenosis with 2-year quality-of-life and cost-effectiveness outcomes, published today in the
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