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Painting picture of breast cancer spread

Date Time Painting picture of breast cancer spread A new study has shed coloured light on how an aggressive breast cancer spreads to vital organs, paving the way for more targeted drug treatments for patients. Published today in Science Advances, the study used fluorescent proteins derived from jellyfish and sea anemones to ‘paint a picture’ of how breast cancer cells adapt and colonise other tissues, in particular the liver and lungs. Postdoctoral Research Fellow at the Olivia Newton-John Cancer Research Institute and La Trobe University’s School of Cancer Medicine, Dr Jean Berthelet, said understanding how cancer cells travel to, and survive in, distant organs, is critical to the development of effective cancer treatments.

New collaboration to tackle tuberculosis

Date Time New collaboration to tackle tuberculosis The optimisation of science and practice relating to tuberculosis (TB) – the world’s oldest and deadliest pandemic – through collaboration, translation research and local solutions is the goal of a new group formed in Melbourne. At the MTBC launch (L-R): Committee members Associate Professor Justin Denholm (Doherty Institute), Dr Anna Coussens (WEHI), Dr Suman Majumdar (Burnet Institute), Associate Professor Sarah Dunstan (Doherty Institute), Dr Khai Huang (Burnet Institute) The Melbourne TB Community (MTBC) will promote collaboration among researchers, practitioners and community to strengthen local capacity and develop a coordinated and critical mass of research.

How to predict severe influenza in hospitalised patients

Published today in Nature Communications, the team from the Peter Doherty Institute for Infection and Immunity (Doherty Institute), Alfred Health and Monash University sought to understand which patients would recover quickly from influenza and which would become severely ill. The four-year project took samples from patients hospitalised with influenza at up to five time points during their hospital stay, and 30 days after discharge. They analysed the breadth of the immune response, enabling them to describe the specific roles of several different types of immune cells, including killer and helper T cells, B cells and innate cells. University of Melbourne Dr Oanh Nguyen, Research Fellow at the Doherty Institute, said two significant findings of the research include understanding the biomarkers that drive recovery and identifying four specific cytokines that cause serious inflammation during influenza virus infection.

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