Abstract
Organ transplant patients have poor immune responses to COVID-19 vaccines; thus designing vaccine strategies to protect this vulnerable population from SARS-CoV-2 infection is crucial.
Effective vaccines against viruses, including vaccines against SARS-CoV-2, induce virus-specific immune memory comprised of cellular and humoral components that together prevent infection following exposure to the virus; however, many of these responses are compromised in solid organ transplant patients. Initial T cell and B cell activation in response to any immune stimuli, including vaccines, requires innate immune activation signals commonly transmitted by pathogen associated molecular patterns ligating pattern recognition receptors expressed on various immune cells. Subsequently, vaccine-induced protective humoral immunity requires collaborative interactions between subsets of CD4+ T cells, including follicular helper T cells (T
Prioritizing Vaccination Strategies for Organ Transplant Recipients by Angela Mohan on July 3, 2021 at 10:02 AM
Science Immunology study by Hector Rincon-Arevalo and colleagues.
The authors note that this presents challenges at both the individual and population levels, since current vaccine protocols may not provide adequate protection to immunosuppressed patients - who could, in turn, become reservoirs for new and dangerous variants of the virus.
As such, Heeger, Larsen, and Segev argue that developing vaccination strategies for transplant recipients should be a high priority in the next wave of research focused on fighting COVID-19. The global scientific response to the SARS-CoV-2 pandemic has been a marvel, the researchers write.
New research suggests prioritized vaccination strategies for organ transplant recipients ANI | Updated: Jul 02, 2021 08:15 IST
Washington [US], July 2 (ANI): In new research, scientists discussed recent evidence - including a recent Science Immunology study by Hector Rincon-Arevalo and colleagues - that points to a diminished immune response to COVID-19 vaccines among organtransplant recipients and others on immunosuppressive drug regimens.
The authors note that this presents challenges at both the individual and population levels, since current vaccine protocols may not provide adequate protection to immunosuppressed patients - who could, in turn, become reservoirs for new and dangerous variants of the virus.
As such, Heeger, Larsen, and Segev argue that developing vaccinationstrategies for transplant recipients should be a high priority in the next wave of research focused on fighting COVID-19. The global scientific response to the SARS-C
Research associates prior encounter with seasonal coronavirus to milder COVID-19 symptoms
A study by Stanford University School of Medicine investigators hints that people with COVID-19 may experience milder symptoms if certain cells of their immune systems remember previous encounters with seasonal coronaviruses the ones that cause about a quarter of the common colds kids get.
These immune cells are better equipped to mobilize quickly against SARS-CoV-2, the coronavirus responsible for COVID-19, if they ve already met its gentler cousins, the scientists concluded.
The findings may help explain why some people, particularly children, seem much more resilient than others to infection by SARS-CoV-2, the coronavirus that causes COVID-19. They also might make it possible to predict which people are likely to develop the most severe symptoms of COVID-19.
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