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Brain’s locus coeruleus may be a sophisticated regulator of learning and behavior Small and seemingly specialized, the brain s locus coeruleus (LC) region has been stereotyped for its outsized export of the arousal-stimulating neuromodulator norepinephrine. In a new paper and with a new grant from the National Institutes of Health, an MIT neuroscience lab is making the case that the LC is not just an alarm button but has a more nuanced and multifaceted impact on learning, behavior, and mental health than it has been given credit for. With inputs from more than 100 other brain regions and sophisticated control of where and when it sends out norepinephrine (NE), the LC s tiny population of surprisingly diverse cells may represent an important regulator of learning from reward and punishment, and then applying that experience to optimize behavior, said Mriganka Sur, Newton Professor of Neuroscience in The Picower Institute for Learning and Memory and the Department of Brain and Cogn

Gabrielle drummondVincent breton provencherMriganka surEmily hendersonDepartment of brainMassachusetts institute of technologyNational institutes of healthCognitive sciencesPicower institute forNational institutesNewton professorPicower instituteMassachusetts instituteமிரகங்க சூர்எமிலி ஹென்டர்சன்துறை ஆஃப் மூளை