The researchers conducted the study in mice with breast cancer and one patient with late-stage pancreatic cancer.
The COVID-19 vaccines designed using bits of genetic information that prime our immune systems to recognize and fight off viral infections have become lifesavers in the global fight to end the pandemic.
Now, the new research has shown that a similar vaccine approach can be used to create personalized vaccines that program the immune system to attack malignant tumors, including breast and pancreatic cancers.
The tailor-made vaccines are designed to target mutated proteins called neoantigens that are unique to a patient’s tumors. Unlike the COVID-19 vaccines made by Moderna and Pfizer/BioNTech that rely on genetic material called mRNA, the personalized cancer vaccines are made using DNA.
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IMAGE: Senior investigator Samuel Klein, MD, (left), in the laboratory with Adewole Okunade, PhD. Klein s team found that NMN improved the ability of insulin to increase glucose uptake in skeletal muscle.. view more
Credit: Matt Miller
A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis.
A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity
COVID-19 vaccine may protect babies of breastfeeding moms futurity.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from futurity.org Daily Mail and Mail on Sunday newspapers.
Edward J. âTedâ Koplar passed away peacefully at his home surrounded by his family April 4, 2021. He was 77 years old.Â
Koplar was known as a pioneer and innovator in the television industry and beyond. A native St. Louisan, he grew hometown favorite KPLR-TV into one of the most successful independent television stations in the country. In a career filled with accomplishments, Koplar also launched Voltron, an animated TV sensation that swept the nation, and pioneered a revolutionary technology that made television interactive. More than anything, those he worked with remember him for his enormous heart and extraordinary kindness.Â
Edward J. âTedâ Koplar
Mazel tov! The whole shtetl buzzed with the news. Chanka, the butcherâs daughter, was engaged to Yankel, the carpenterâs son. It was a local match, so the whole town got involved in the wedding preparations. A week before the wedding, Chanka could be found sewing the last few stitches on he…