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Protein discovery could help prevent cancer t

Protein discovery could help prevent cancer t
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Zhaokang-cheng
Boyang-jason-wu
Jingrui-chen
Washington-state-university
National-institutes-of-health
National-cancer-institute
College-of-pharmacy
Blood-institute
National-heart
Method-of-research
Cardiovascular-research
Washington-state

Study identifies protein that could be the key to improving heart attack treatment outcomes

Study identifies protein that could be the key to improving heart attack treatment outcomes A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack. Published in the Journal of Biological Chemistry, the research suggests that protein kinase A (PKA) plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy, the treatment used to unblock arteries and restore blood flow after a heart attack. Our study has found that turning off a gene that controls this protein activity increased necrotic cell death and led to more heart injury and worse heart function following heart attack in a rodent model. With further research, this discovery could ultimately lead to the development of a small-molecule drug that could intervene in that pathway to limit or prevent heart muscle cell death after reperfusion therapy.

Zhaokang-cheng
Emily-henderson
Washington-state-university
College-of-pharmacy
Biological-chemistry
Heart
Heart-attack
Protein
Ntioxidant
Flood
Ell
Ell-death

Target protein identified for improving heart attack treatment

A new study led by researchers at Washington State University has identified a protein that could be the key to improving treatment outcomes after a heart attack. Published in the Journal of Biological Chemistry, it suggests that protein kinase A (PKA) plays a role in heart muscle cell necrosis, a major type of cell death that commonly occurs after reperfusion therapy, the treatment used to unblock arteries and restore blood flow after a heart attack.

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Jingrui-chen
Peng-xia
Yuening-liu
Zhaokang-cheng
Washington-state-university
Human-development
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Biological-chemistry
Pharmaceutical-sciences

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