AZ vaccine candidate works better given nasally, animal study shows
doi:10.1038/nindia.2021.69 Published online 12 May 2021
A new study involving the University of Oxford-AstraZeneca COVID-19 vaccine in ferrets shows that nasal delivery, instead of the current intramuscular administration, might potentially improve the vaccine’s effectiveness
1.
The ‘ChAdOx1 nCoV-19’ vaccine, known as ‘Covishield’ in India and ‘AZD1222’ in other parts of the world, was found to induce effective immune responses in ferrets (
Mustela putorius furo) and reduce viral load in nasal-wash and oral swab samples. The study was carried out by scientists at Australia’s science agency the Commonwealth Scientific and Industrial Research Organisation with funding from the Coalition for Epidemic Preparedness Innovations (CEPI).
Dr. Selina Mahmood: I was scared. . I wavered. (Photo: Facebook) The first year of Selina Mahmood s neurology residency at Henry Ford Health System was scary, historic and unusually instructive. Daily experiences were so vivid as Covid escalated rapidly that the physician-in-training kept a journal and turned it into a book, A Pandemic in Residence: Essays from a Detroit Hospital. It’s part-diary of an eventful March through December last year, and part-essays with philosophic reflections and literary references. Quotes and namechecks include Yeats, Joan Didion, Noam Chomsky and Vladimir Nabokov. Dr. Mahmood recalls the chilling reality of a turning point last spring:
Dr. Selina Mahmood: I was scared. . I wavered. (Photo: Facebook) The first year of Selina Mahmood s neurology residency at Henry Ford Health System was scary, historic and unusually instructive. Daily experiences were so vivid as Covid escalated rapidly that the physician-in-training kept a journal and turned it into a book, A Pandemic in Residence: Essays from a Detroit Hospital. It’s part-diary of an eventful March through December last year, and part-essays with philosophic reflections and literary references. Quotes and namechecks include Yeats, Joan Didion, Noam Chomsky and Vladimir Nabokov. Dr. Mahmood recalls the chilling reality of a turning point last spring:
CSIRO
CSIRO, Australia’s national science agency, has published the peer-reviewed results of its independent preclinical evaluation of the University of Oxford-AstraZeneca COVID-19 vaccine in an animal model, conducted in early 2020.
Peer-reviewed results from last year’s preclinical evaluation of the University of Oxford-AstraZeneca COVID-19 vaccine have been published today in the scientific journal npj Vaccines.
CSIRO, Australia’s national science agency, conducted the independent preclinical evaluation of the vaccine in an animal model in early 2020.
The study was conducted in partnership with the Coalition for Epidemic Preparedness Innovations (CEPI). Quality assured and quality-controlled data was shared last year with CEPI and the University of Oxford to support human clinical trials.
A second wave of the pandemic has caught the government napping and toppled an already-weak healthcare infrastructure in the country. What will be the l.