The relentless pursuit of detecting Alzheimer’s has posed a grueling battle for families and the medical community, but a simple eye scan may help ease that burden.
Alnylam Pharmaceuticals has announced positive interim results for the ongoing single ascending dose portion of the phase 1 study of ALN-APP, an investigational RNAi therapeutic targeting amyloid precursor protein (APP) in development for the treatment of Alzheimer’s disease and cerebral amyloid angiopathy (CAA).
– First Clinical Study of a Central Nervous System-Administered RNAi Therapeutic Showed Rapid and Robust Target Engagement with Sustained Effect Over 6 Months with a Single Dose –
– ALN-APP Continues to Demonstrate an Encouraging Clinical Safety and Tolerability Profile –
– Multiple-dose Portion of Study, Part B, Being Initiated in Approved Regions –