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New study could help overcome SARS-CoV-2 virus s defenses The coronavirus that causes COVID-19 has demonstrated a stubborn ability to resist most nucleoside antiviral treatments, but a new study led by an Iowa State University scientist could help to overcome the virus s defenses. The study, published recently in the peer-reviewed journal Science, details the structure of a critical enzyme present in SARS-CoV-2, the coronavirus that causes COVID-19. This enzyme, known as the proofreading exoribonuclease (or ExoN), removes nucleoside antiviral medications from the virus s RNA, rendering most nucleoside analogs-based antiviral treatments ineffective. The new study presents the atomic structures of the ExoN enzyme, which could lead to the development of new methods for deactivating the enzyme and opening the door to better treatments for patients suffering from COVID-19.

Emily hendersonRoyj carver department of biochemistryIowa state universityMolecular biology at iowa state universityMolecular biologyIowa stateஎமிலி ஹென்டர்சன்ஐயுவா நிலை பல்கலைக்கழகம்மூலக்கூறு உயிரியல் இல் ஐயுவா நிலை பல்கலைக்கழகம்மூலக்கூறு உயிரியல்ஐயுவா நிலை