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IMAGE: A possible mechanism for the formation of chiral N,N-acetal via reaction between 2-aminobenzamide and α-ketoester in presence of chiral bis(imidazoline)-phosphoric acid catalyst view more
Credit: Picture courtesy: Shuichi Nakamura from NITech
A lot of our medicines and other bioactive drugs are based on chemical structures called enantiomers molecules that are mirror images of each other and are non-superimposable. Notable among them are chiral N,N-acetals contained in diuretic drugs like bendroflumethiazide and thiabutazide, used to treat high blood pressure and edema. Because an enantiomer and its mirror image version often have different biological activities, with only one of them having pharmacological utility, an enantioselective or asymmetric synthesis yielding the desired enantiomer in greater amounts is highly desirable.
Tiny nanoparticles can be furnished with dyes and could be used for new imaging techniques, as chemists and physicists at Martin Luther University Halle-Wittenberg (MLU) show in a recent study. The researchers have also been the first to fully determine the particles internal structure. Their results were published in the renowned journal
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Credit: Credit: Craig S. Day (ICIQ)
Negishi cross-coupling reactions have been widely used to form C-C bonds since the 1970s and are often perceived as the result of two metals (i.e zinc and palladium/nickel) working in synergy. But like all relationships, there is more under the surface than what we first expected. PhD student Craig Day and Dr. Rosie Somerville from the Martin group at ICIQ have delved into the Negishi cross-coupling of aryl esters using nickel catalysis to understand how this reaction works at the molecular level and how to improve it. The results have been published in
Credit: Children s Hospital Colorado
Results of study by Children s Hospital Colorado, presented at the Society for Maternal Fetal Medicine s Annual Meeting, show a third of patients not needing narcotic pain pills after c-section
Aurora, Colo. (Jan. 28, 2021) In a retrospective analysis of cesarean deliveries from 2015 through 2020, a team of doctors from the Colorado Fetal Care Center at Children s Hospital Colorado (Children s Colorado) found that using a wound infusion pump in combination with enhanced recovery efforts such as removing urinary catheters earlier and walking around the same day of surgery can reduce opioid use by more than 80%. Also notable, the researchers found that a third of patients never took a single narcotic pain pill after the cesarean delivery.
Pseudonocardia and
Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens. Surprisingly, these metabolites lack common structural features across bacteria from different geographic locations, even though the ants share a common ancestor. Now, researchers report in
ACS Central Science they have identified the first shared antifungal compound among many of these bacteria across Brazil. The compound could someday have medical applications.
Attine ants originated as one species at a single location in the Amazon 50 million years ago. They have evolved to 200 species that have spread their farming practices throughout South and Central America. In exchange for food, bacteria at these farms produce small molecules that hold pathogenic fungi such as