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Study reveals significant role of ADAMTS1 protein in uveal melanoma Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye. tumors are composed not only of a mass of cells that grow uncontrollably but also of the environment they create during their growth together creating what is known as the tumor microenvironment . Within this environment, there are proteins that remodel it, known as extracellular proteases, which are capable of inhibiting or contributing to tumor growth and metastasis. They do this by modifying non-cellular elements of the tumor microenvironment that form the so-called extracellular matrix.

Juan carlos rodrEmmanuelle charpentierJennifera doudnaEmily hendersonAndalusian government centre for genomicsUs national cancer instituteUniversity of granadaOncological researchGranada andalusian government centreNobel prizeCancer genome atlas projectCancer instituteஇம்மானுவேல் சார்பென்டிர்எமிலி ஹென்டர்சன்அண்டலூசின் அரசு மையம் க்கு மரபியல்எங்களுக்கு தேசிய புற்றுநோய் நிறுவனம்