A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.
In a Phase I clinical trial, researchers at Vanderbilt-Ingram Cancer Center showed that the DNA methylome can be modified in glioblastoma. Their findings pave a way for understanding how the epigenome can be manipulated and may help design future epigenetic studies in glioblastoma treatment.
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