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Weizmann Institute of Science Our brain has On and Off switches for all its activities, and maintaining a balance between the two is crucial for our health and well-being. For instance: Epileptic seizures occur when the On signals run amok in the cortex, while people with Parkinson’s disease have difficulty using their muscles because of an excess of Off signals in the brain’s motor regions. In memory circuits, an overzealous On can force irrelevant memories upon us, as in posttraumatic stress disorder, whereas an overly active Off can prevent us from remembering anything at all. In a new study reported in the Proceedings of the National Academy of Sciences (PNAS), researchers at the Weizmann Institute of Science, in collaboration with scientists from the University of Tübingen, have revealed how the brain keeps the On-Off balance steady. They discovered that this balance is programmed into the basic mechanisms through which individual neurons connect with one another.

Eyal weinrebElisha mosesNirit sukenikMenahem segalOleg vinogradovAnna levinaWeizmann physics of complex systems departmentProceedings of the national academy sciencesWeizmann institute of scienceWeizmann neurobiology departmentNational academyWeizmann instituteComplex systems departmentNeurobiology departmentPost traumatic stress disorderஎலிஷா மோஸஸ்