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Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems.

admin Eugenie Nepovimova,Lucie Svobodova,Rafael Dolezal,Vendula Hepnarova,Lucie Junova,Daniel Jun,Jan Korabecny,Tomas Kucera,Zuzana Gazova,Katarina Motykova,Jana Kubackova,Zuzana Bednarikova,Jana Janockova,Catarina Jesus,Luisa Cortes,Joao Pina,Danijela Rostohar,Carlos Serpa,Ondrej Soukup,Laura Aitken,Rebecca E Hughes,Kamil Musilek,Lubica Muckova,Petr Jost,Marketa Chvojkova,Karel Vales,Martin Valis,Zofia Chrienova,Katarina Chalupova,Kamil Kuca Eugenie Nepovimova Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. Lucie Svobodova Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.

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Necrostatin-1 counteracts aluminum's neurotoxic effects – Engineering Evil

  New studies in mice support toxic role of aluminum in neurodegenerative conditions, according to report in Restorative Neurology and Neuroscience Amsterdam, NL, August 2, 2013 – Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer’s disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum’s neurotoxic effects. Researchers have long focused on why neurons die in degenerative diseases. One process is apoptosis, a form of gene-directed programmed cell death which removes unnecessary, aged, or damaged cells. When neurons die as a result of stroke, trauma, or other insult, the process is known as necrosis. Recently, a new type of necrosis, necroptosis (programmed necrosis), has been implicated in the cell demise p

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AB Science communicates the results from phase 2B/3 study evaluating masitinib in Alzheimer's disease

Bruno Dubois Bruno Dubois is currently Professor of Neurology at the Neurological Institute of the Salpétrière University Hospital at Paris, University Pierre et Marie Curie Paris VI. He is Director of the Behavioural Neurology Department and of the Dementia Research Center at the Hospital. He is also Director of the Research Unit Inserm U-610 of the ICM (Institut du Cerveau et de la Moelle Epinière) of the Hospital. He is coordinator of the National Reference Center on Rare Dementias and of the National Reference Center for young-onset Alzheimer patients. He is President of the Scientific Committee of France-Alzheimer and of IFRAD (International Fund Raising for Alzheimer s disease), consultant for the Human Frontier Program and Expert of the French Agency of Drugs. He is a member of the European Alzheimer Disease Consortium (EADC). He has published on anatomical and biochemical studies on the central cholinergic systems in rodents and humans; on cognitive neuropharmacology; an

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AB Science communicates the results from phase 2B/3 study evaluating masitinib in Alzheimer's disease Paris Stock Exchange:AB

AB Science communicates the results from phase 2B/3 study evaluating masitinib in Alzheimer's disease Paris Stock Exchange:AB
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AB Science communicates the results from phase 2B/3 study evaluating masitinib in Alzheimer's disease – IT Business Net

AB Science communicates the results from phase 2B/3 study evaluating masitinib in Alzheimer's disease – IT Business Net
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