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Research Article Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study Shoya Iwanami , Roles Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing Affiliations Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan, interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing Affiliations Departmen

Japan generalMirjamee kretzschmarSmoking research foundationLife science foundation of japanLos alamos national laboratoryTechnology agencyYasuda medical foundationMitsui life social welfare foundationJapan prize foundationSuzuken memorial foundationTechnology foundationJapan agency for medical researchJapan society for the promotion of scienceCoordination centerDrug administrationTakeda science foundation