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IMAGE: Model of insulin inhibitory receptor inceptor (in black) desensetizing the insulin recptor (in color) on a pancreatic beta cell. Insulin in blue. view more
Credit: Helmholtz Zentrum München
Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum Muenchen, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific community celebrates 100 years of insulin and 50 years of insulin receptor discovery. The blocking of inceptor function leads to an increased sensitisation of the insulin signaling pathway in pancreatic beta cells. This might allow protection and regeneration of beta cells for diabetes remission.