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IMAGE: In Huntington s Disease, axonal transport is defective and this leads to neuronal degeneration. In this work, we found that the protein mutated in Huntington s Disease, called huntingtin (HTT), needs to. view more
Credit: by University of Trento
Huntington s disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and cognitive impairment. That neuronal traffic is impaired in this disease has been very well known for several years. But that this deranged trafficking could be ameliorated by increasing huntingtin methylation was not yet known. The findings emerged from an international research work coordinated by the University of Trento and published in