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Researchers identify proteins that contribute to the pathogenicity of COVID-19 virus Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease. Using advanced genetic engineering techniques developed at Texas Biomed, they systematically deleted the genetic code for five of the virus s accessory proteins, one at a time, to see how each one affected the virus s ability to spread and cause illness. The research was published online this month in the Journal of Virology. They found two proteins that seem to contribute most to the virus s pathogenicity, or ability to cause COVID-19 disease. When individually lacking those proteins, the virus did not replicate as much as the natural virus in cells, suggesting they play a critical role in its spread. In contrast, spread was not significantly reduced when the other proteins were deleted.

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