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Cholesterol starvation kills lymphoma cells
Northwestern Medicine scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food – cholesterol – which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death.
The research looked at lymphoma cells, but the new experimental drug from Northwestern could be effective in other cancers with a similar appetite for cholesterol such as kidney and ovarian cancer, the scientists said.
The study was published this month in the Journal of Biological Chemistry and builds upon prior work published by the group.
Drug is being developed for clinical trials Drug selectively attacks cancer cells, leaves normal cells unharmed
CHICAGO - Scientists at Northwestern Medicine have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol - which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death.
Although the research looked at lymphoma cells, scientists say the new experimental drug from Northwestern could be effective in other cancers with a similar appetite for cholesterol, such as kidney and ovarian cancer.