infection. look at delta in the blue boxes. as you go the time since the vaccine and look at the weeks which are showed on the bottom line, you get a diminution against delta, but a profound diminution below 40% effect iness with delta. when you boost, not only do you bring it up to delta in the blue. but also to omicron. what does all of this tell us? last slide. we are in the situation we are now facing a very important delta surge and we re looking over our shoulder at an oncoming omicron surge. clearly unvaccinated individuals as jeff said in the beginning, are really at a high risk of serious involvement including hospitalizations. the fully vaccinated are doing much better off, but as i ve shown you in the previous five or six slides, the optimum
omicron specific situations. in this study, one looked at three separate vaccines. the mrna of moderna. the pfizer, and then the add 26 j&j follow bid an mrna boost. if you look at the times two, which means a standard vaccination, and then take a look at the neutralization following the boost. the increment of that is really rather profound. 19 times for the one on the left. 27 times for the one in the middle. and four times for the one on the right. next slide. now also if you look at the neutralization of multiple different variants by analysis and take a look again at two separate studies, one from the vaccine research center at nih. and one from duke university. note on the left panels four
dose, it goes well within the protective range. next slide. if you look at now convalescent serum and look at each of the panels, on the left you have a convalescent serum six months after infection. again, the level of protection that would be projected from the antibody levels is very low as you see with omicron, the low level with the circles that are red. 12 months later, it even gets worse. but take a look at what happens if you take a person whose convalescent but you boost that person now with a dose of pfizer and wait one month. the red circles go way up into the protective range. next slide. and then if you look at actual clinical issues, take a look into a uk study about individuals who had symptomatic
weeks following the second dose, look specifically at the pink bar. there you see a rather low level of neutralization with omicron. however, if you look at two weeks post the third or booster dose, note how much it goes up. for example, if you look at the omicron comparing in the duke line, you see it is about 2,002. after a second dose, it s only 62. a dramatic increase. next slide. another example, if you look at the sensitivity of variants to neutralization, by people who were vaccinated with the pfizer vaccine, if you look again, five months after the second dose, and look under omicron, the red circles, nominal. in other words, virtually no degree of neutralization protection. again, one month after the third
thank you all. i ll turn things over to dr. fauci. thank you very much, doctor. i d like to spend the next couple minutes talking about the importance of covid-19 booster shots both in the current delta surge and in the inevitable upcoming omicron surge. so if i could have the next slide, let s take a look at some of the data that fortifies what i just said. this is a recently published study in the new england journal. looking at individuals 50 or older who received the booster about five months after a second dose of the pfizer. there was a 90% lower mortality due to covid-19 than participants who did not receive a boost. the mortality is low in people who were vaccinated anyway, however, it goes down to practically negligible values. if you look at the blue line compared to the pink line. next slide. now, let s take a look at