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Membraneless organelles in cells contain high concentrations of semi-extractable RNAs, which could serve as potential biomarkers and drug targets. However, the identification and characterization of these RNAs have been limited. Japanese researchers have now developed a novel bioinformatic pipeline to define and analyze semi-extractable RNAs, which has led to the identification of over 1000 RNAs involved in membraneless organelle formation. This study paves the way for future investigations into RNA-centric phase separations.
Waseda
Niigata
Japan
Suita
Osaka
Tokyo
Nippon
Takeshi-chujo
Michiaki-hamada
Chao-zeng
Tetsuro-hirose
Nucleic-acids-research