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Low HDL Tied to Parkinson s Disease | Physician s Weekly

Feb 10, 2021 Longitudinal study is first to explore HDL variability and PD Lower high density lipoprotein (HDL) cholesterol levels and greater HDL variability were associated with higher incidence of Parkinson’s disease (PD), a large, nationwide, population-based, longitudinal study in Korea found. In this study, “baseline HDL-C level, mean HDL-C level, and HDL-C variability was associated with the risk of PD incidence, regardless of potential confounding factors,” wrote Do-Hoon Kim, MD, of Korea University College of Medicine, Ansan, and co-authors in “HDL has reverse cholesterol transport and a wide range of other functions, including anti-oxidation, anti-inflammation, pro-endothelial function, anti-thrombosis, and modulation of immune function,” they noted. “Because oxidative stress and chronic inflammation may be associated with PD, HDL reduction can affect the development of PD.”

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