In 2014 ResTORbio spun off out of Novartis and went public to try a longevity drug as a vaccine-potentiating agent in the elderly. The company was led by Dr. Joan Mannick, a physician with deep interest in aging. The trial failed in Phase III providing valuable experience, and her work continues.
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BOSTON, April 22, 2021 /PRNewswire/ Life Biosciences, a pioneering life sciences company targeting the biology of aging, today announced the publication of preclinical research demonstrating clinical benefit of its chaperone-mediated autophagy activator platform in mice models of Alzheimer s disease. The article, titled
Cell on April 22, 2021.
Chaperone-mediated autophagy (CMA) controls the levels of soluble proteins in cells. It has been proposed that the age-related decline of CMA leads to an increased concentration of insoluble proteins that may play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer s disease. This study demonstrated that the upregulation of CMA with one of Life Biosciences tool oral compounds significantly improved neurologic function and decreased the accumulation of insoluble protein aggregates in two different mouse models of Alzheimer s disease, even after the onset of neurologic dysfunct
Life Biosciences to Present at 5th Stanford Drug Discovery Symposium
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BOSTON, April 14, 2021 /PRNewswire/ Life Biosciences, a pioneering life sciences company targeting the biology of aging, today announced that Joan Mannick, MD, Head of Research and Development, will participate in the 5
th Stanford Drug Discovery Symposium (SDDS 2021) being held virtually on April 19-20, 2021.
5th Stanford Drug Discovery Symposium (SDDS 2021)
Session VIII: Discovery Research II
Presentation: Targeting the Biology of Aging to Prevent or Treat Aging-related Diseases
Moderators: Marc Tessier-Lavigne, PhD, and Kuldev Singh, MD
Tuesday, April 20, 2021
2:45pm ET / 11:45am PT
The Stanford Drug Discovery Symposium takes advantage of the collective experience and expertise of participants to cover a broad range of policy, research, and venture topics. This symposium provides an invaluable forum for interdisciplinary exchange at the foref
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