The goal of obesity management is to improve health. Sustained weight loss of more
than 10% overall bodyweight improves many of the complications associated with obesity
(eg, prevention and control of type 2 diabetes, hypertension, fatty liver disease,
and obstructive sleep apnoea), as well as quality of life. Maintenance of weight loss
is the major challenge of obesity management. Like all chronic diseases, managing
obesity requires a long-term, multimodal approach, taking into account each individual s
treatment goals, and the benefit and risk of different therapies.
Prospective data from nearly 24,000 people with diabetes showed that longer diabetes duration significantly linked with an increased heart failure incidence.
Findings suggest that at time of type 2 diabetes diagnosis some might not benefit from metformin as first-line treatment. Dual or other therapy may be preferable.
Prospective data from almost 20,000 people with type 2 diabetes show that proton pump inhibitor use is linked with significantly more cardiovascular disease events and all-cause death than nonuse.