Study highlights genome altering can help to treat human retinal degeneration ANI | Updated: Jan 20, 2021 09:14 IST
New York [US], January 20 (ANI): A study published in journal Human Gene Therapy shows that gene editing therapies, including CRISPR-Cas frameworks, offer the possibility to address transformations causing inherited retinal degenerations, a leading cause of blindness.
The findings highlight the technological advances in gene editing, continuing safety concerns, and strategies to overcome these challenges.
Kanmin Xue, University of Oxford, and co-authors state, Currently, the field is undergoing rapid development with a number of competing gene editing strategies, including allele-specific knock-down, base editing, prime editing, and RNA editing, are under investigation. Each offers a different balance of on-target editing efficiency versus off-target risks.