Using a multi-pronged approach including immunology, germ-free models, neuroscience, and behavioral assays, a team led by scientists at Harvard Medical School and the Massachusetts Institute of Technology investigated the mechanistic underpinnings of immune dysfunction in animal models of autism. The study showed changes in the gut microbiota of pregnant mice following immune activation affect chromatin accessibility in a subset of T cells in their offspring, priming them for immune activation and inflammatory attacks of the gut after birth.
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Caption: A diverse array of speakers including a panel of students, faculty, and staff discussed Outreach and Opportunities in STEM (left to right and top to bottom): Laura Schulz, Eboney Hearn, Junyi Chu, Kailande Cassamajor, Hector De Jesus Cortes, Tyler Bonnen, and Liora Jones. Credits: Image courtesy of the Picower Institute.
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A powerful series of speakers at the Picower Institute for Learning and Memory’s biennial Spring Symposium, Early Life Stress and Mental Health, blended personal stories and rigorous research to demonstrate that while remedying the lifelong toxic stress and disadvantage many people incur during childhood can be difficult, it is by no means intractable.
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