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Machine learning can help predict patient response to cancer immunotherapy

Algorithm gives insights into the biology behind an effective immune response

Catherine wuAlexander barasGiacomo oliveiraJohn william sidhomBristol myers squibbByamy monepublishedPetra ross macdonaldJohns hopkins kimmel comprehensive cancer centerBloomberg kimmel institute for cancer immunotherapyJohns hopkins kimmel cancer centerDana farber cancer instituteJohns hopkins university school of medicineHarvard medical schoolKimmel instituteJohns hopkins university schoolDrew pardoll

Machine learning algorithm predicts a tumor s response to immune checkpoint blockade

Predicting which patients will respond well to treatment is a quandary that has plagued the field of cancer immunotherapy for more than four decades.

Catherine wuAlexander barasGiacomo oliveiraJohn william sidhomBristol myers squibbEmily hendersonPetra ross macdonaldJohns hopkins kimmel cancer centerBloomberg kimmel institute for cancer immunotherapyLab diagnostics automationHarvard medical schoolDana farber cancer instituteJohns hopkins university school of medicineLab diagnostics automation industryKimmel instituteWilliam sidhom

Connecting early response and later outcome in COVID-19, centenarians unique microbiomes, T cell exhaustion in cancer, and more

Connecting early response and later outcome in COVID-19, centenarians unique microbiomes, T cell exhaustion in cancer, and more
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Jon rennhackVincent miaoRyan tewheyCatherine wuPardis sabetiChao daiGiacomo oliveiraSagar gosaiRamnik xavierKathleen yatesAlex shalekSteven reillyKim stegmaierNicholas haining merckAnna owingsCarly ziegler

Personalized vaccine produces long-lasting anti-tumor response in patients with melanoma, study shows

Date Time Personalized vaccine produces long-lasting anti-tumor response in patients with melanoma, study shows Four years after patients with melanoma were treated with a personalized cancer vaccine, the immune response kindled by the vaccine remains robust and effective in keeping cancer cells under control, researchers at Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad Institute of MIT and Harvard report in a new study. The findings, published online today by the journal Nature Medicine, demonstrate the staying power of the immune response generated by the vaccine, known as NeoVax, which works by targeting specific proteins on each patient’s tumor cells. The researchers found that, nearly four years after vaccination, the patients’ immune system cells were active not only against tumor cells with those distinctive proteins, but also spread to other proteins found in those patients’ tumor cells.

United statesMassachusetts institute of technologyCity ofUnited kingdomDana farber cancer institutePavan bachireddyRobert reddJason pyrdolGiacomo oliveiraCharlesh yoonAdriennem luomaPatricka ottAnita giobbie hurderWandi zhangDanh barouchZoe ciantra

Vaccine produces long-lasting anti-tumor response in patients with melanoma

E-Mail BOSTON - Four years after patients with melanoma were treated with a personalized cancer vaccine, the immune response kindled by the vaccine remains robust and effective in keeping cancer cells under control, researchers at Dana-Farber Cancer Institute, Brigham and Women s Hospital, and the Broad Institute of MIT and Harvard report in a new study. The findings, published online today by the journal Nature Medicine, demonstrate the staying power of the immune response generated by the vaccine, known as NeoVax, which works by targeting specific proteins on each patient s tumor cells. The researchers found that, nearly four years after vaccination, the patients immune system cells were active not only against tumor cells with those distinctive proteins, but also spread to other proteins found in those patients tumor cells.

United statesMassachusetts institute of technologyDana farber cancer instituteCity ofUnited kingdomPavan bachireddyRobert reddJason pyrdolGiacomo oliveiraCharlesh yoonAdriennem luomaPatricka ottAnita giobbie hurderWandi zhangDanh barouchZoe ciantra