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Gene variants increase risk of clogged arteries

Gene variants increase risk of clogged arteries
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COVID-19 Can Kill Heart Cells and Interfere With Contraction

COVID-19 Can Kill Heart Cells and Interfere With Contraction Study reveals details of how coronavirus infects the heart and heart damages cardio myocytes A study from Washington University School of Medicine in St. Louis provides evidence that the coronavirus can invade and replicate inside heart muscle cells, causing cell death and interfering with heart muscle contraction. The image of engineered heart tissue shows human heart muscle cells (red) infected with COVID-19 (SARS-CoV-2) (green). Image by Lina Greenberg. March 12, 2021 Since early in the pandemic, COVID-19 has been associated with heart problems, including reduced ability to pump blood and abnormal heart rhythms. But it has been an open question whether these problems are caused by the virus infecting the heart, or an inflammatory response to viral infection elsewhere in the body. Such details have implications for understanding how best to treat coronavirus infections that affect the heart. A new study from Washing

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COVID-19 heart damage may result from viral invasion

A new study provides evidence that COVID-19 patients’ heart damage results from the virus invading and replicating inside heart muscle cells, leading to cell death and interfering with heart muscle contraction. The researchers used stem cells to engineer heart tissue that models the human infection and could help in studying the disease and developing possible therapies. “Early on in the pandemic, we had evidence that this coronavirus can cause heart failure or cardiac injury in generally healthy people, which was alarming to the cardiology community,” says senior author Kory J. Lavine, associate professor of medicine at Washington University School of Medicine in St. Louis.

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COVID-19 can kill heart muscle cells, interfere with contraction

COVID-19 can kill heart muscle cells, interfere with contraction
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Imaging shows who'll benefit from breast cancer hormone therapy

An imaging test that measures the function of estrogen receptors in breast cancer cells can distinguish patients likely or unlikely to benefit from hormone therapy, a new study shows. Hormone therapy is commonly given as a targeted treatment for women whose cancer cells carry receptors for estrogen. But the therapy only works for about half of all patients. Until now, there hasn’t been a good way to reliably predict who will benefit and who will not. In a small phase 2 clinical trial, researchers showed that the cancers of all patients with working estrogen receptors remained stable or improved on hormone therapy, and progressed in all women with nonfunctional estrogen receptors.

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