Skin Cell Atlas Uncovers Origin of Inflammatory Skin Disease
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January 22, 2021
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Scientists have used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. This highly detailed map of skin reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease. In addition, it uncovered that skin from eczema and psoriasis patients share many of the same molecular pathways as developing skin cells. This offers potential new drug targets for treating these painful skin diseases.
This work is published in
UK scientists discover how psoriasis and eczema develop in skin cells
By Nilima Marshall
UK scientists have discovered how chronic conditions such as psoriasis and eczema develop in skin cells which, they believe, could open doors for potential new treatments.
Researchers have found that cells from skin with eczema and psoriasis share some of the same cellular mechanisms as developing healthy skin cells.
The team said the findings, published in the journal Science, could help in the development of new drugs targeting inflammatory skin disease.
Psoriasis, which affects around 2% of people in the UK, is caused by an increased production of skin cells.
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Scientists have created a highly detailed map of skin, which reveals that cellular processes from development are re-activated in cells from patients with inflammatory skin disease. The researchers from the Wellcome Sanger Institute, Newcastle University and Kings College London, discovered that skin from eczema and psoriasis patients share many of the same molecular pathways as developing skin cells. This offers potential new drug targets for treating these painful skin diseases.
Published on 22nd January in
Science, the study also provides a completely new understanding of inflammatory disease, opening up new avenues for research on other inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
UK scientists have discovered how chronic skin conditions such as psoriasis and eczema develop.
Researchers from Newcastle University found cells from skin with eczema and psoriasis share many of the cellular mechanisms as developing healthy skin cells.
The team said the findings, published in the journal Science, could help in the development of new drugs targeting inflammatory skin disease.
Researchers from Newcastle University found cells from skin with eczema and psoriasis share many of the cellular mechanisms as developing healthy skin cells
Psoriasis, which affects around two per cent of people in the UK, is caused by an increased production of skin cells.