Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of
diabetes worldwide. The number affected is increasing rapidly with alarming trends
in children and young adults (up to age 40 years). Early detection and proactive management
are crucial for prevention and mitigation of microvascular and macrovascular complications
and mortality burden. Access to novel therapies improves person-centred outcomes beyond
glycaemic control. Precision medicine, including multiomics and pharmacogenomics,
hold promise to enhance understanding of disease heterogeneity, leading to targeted
therapies.
The COVID-19 pandemic has disproportionately affected certain groups, such as older
people (ie, >65 years), minority ethnic populations, and people with specific chronic
conditions including diabetes, cardiovascular disease, kidney disease, and some respiratory
diseases. There is now evidence of not only direct but also indirect adverse effects
of COVID-19 in people with diabetes. Recurrent lockdowns and public health measures
throughout the pandemic have restricted access to routine diabetes care, limiting
new diagnoses, and affecting self-management, routine follow-ups, and access to medications,
as well as affecting lifestyle behaviours and emotional wellbeing globally.
Diabetic ketoacidosis is a life-threatening metabolic crisis that can occur at presentation
of type 1 diabetes, with acute (potentially fatal) complications including cerebral
oedema and arrhythmias, and longer-term evidence of worsening glycaemic control1 and
neurocognitive deficits in those presenting with diabetic ketoacidosis2 compared to
those presenting without.
Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.