colleagues, john hardie and colleagues, john hardie and colleagues at the ucl, 30 years ago. and we have been trialling these sort of approach for the last 20 years. so this really is a major step, that we are able to get drugs into the brain. clearly, amyloid has some effects on cognition, and so far, to do so reasonably safely. but there are lots of caveats here. and we have heard some of them already. we need to know whether the effects that we are seeing on cognitive change have meaningful benefits for patients, and whether these are sustained. we need to make sure that we can give these drugs safely. there is going to be some major cost implications. and we need to gear up the national health service to be able to deliver these drugs, which, as fergus walsh was talking about, would require a major step change. but if nothing more, this is a demonstration that alzheimer s is a
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