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Algiax Pharmaceuticals Announces Positive Interim Analysis of Phase 2a Study with Lead Candidate AP-325 in Chronic Neuropathic Pain

Gene-silencing injection reverses pain in mice

Share An experimental pain treatment tested in mice targets ion channels on sensory nerves, shown above in the human spinal cord. Biophoto Associates/Science Source Gene-silencing injection reverses pain in mice Mar. 10, 2021 , 2:00 PM Swallowing an oxycodone pill might quiet nerves and blunt pain, but the drug makes other unwanted visits in the brain to centers that can drive addiction and suppress breathing. Now, a study in mice shows certain types of pain can be prevented or reversed without apparent side effects by silencing a gene involved in pain signaling. If the approach weathers further testing, it could give chronic pain patients a safer and longer lasting option than opioids.

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