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Algiax Pharmaceuticals Announces Positive Interim Analysis of Phase 2a Study with Lead Candidate AP-325 in Chronic Neuropathic Pain

Data Monitoring Committee recommends continuation of the study with no safety alerts within the study population Company is ramping up patient recruitment by doubling number of countries

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Gene-silencing injection reverses pain in mice

Share An experimental pain treatment tested in mice targets ion channels on sensory nerves, shown above in the human spinal cord. Biophoto Associates/Science Source Gene-silencing injection reverses pain in mice Mar. 10, 2021 , 2:00 PM Swallowing an oxycodone pill might quiet nerves and blunt pain, but the drug makes other unwanted visits in the brain to centers that can drive addiction and suppress breathing. Now, a study in mice shows certain types of pain can be prevented or reversed without apparent side effects by silencing a gene involved in pain signaling. If the approach weathers further testing, it could give chronic pain patients a safer and longer lasting option than opioids.

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Ionis-pharmaceuticals

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