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Metabolite in urine predicts diabetic kidney failure 5-10 years early; oral therapeutic drug shows promise in mice

Metabolite in urine predicts diabetic kidney failure 5-10 years early; oral therapeutic drug shows promise in mice
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Urine Metabolite Forecasts Diabetic Kidney Failure, Drug Shows Promise

Urine Metabolite Forecasts Diabetic Kidney Failure, Drug Shows Promise
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Metabolite in urine predicts diabetic kidney

High urine levels of adenine, a metabolite produced in the kidney, were associated with a higher risk of kidney failure in three international research cohorts, a team from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.

Metabolite in urine predicts diabetic kidney failure 5–10 years early: Oral therapeutic drug shows promise in mice

Metabolite in urine predicts diabetic kidney failure 5–10 years early: Oral therapeutic drug shows promise in mice
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Urine levels of adenine found to be predictive and causative biomarker of diabetic kidney disease

Urine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported Aug. 24 in the Journal of Clinical Investigation.

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