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Human genome reboot better reflects global population

Human pangenome ushers in new age of genetic diagnosis

 PARIS Scientists on Wednesday unveiled the first draft of a human “pangenome”, a more diverse and accurate DNA blueprint for our species that they hope will help shed light on a range of diseases.The announcement was hailed by researchers as a major scientific milestone that “heralds a new age of genetic diagnosis”. The first human genome was sequenced in 2003, providing a

Human pangenome reference will enable more complete and equitable understanding of genomic diversity

Human pangenome reference will enable more complete and equitable understanding of genomic diversity
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Scientists unveil the first human pangenome : a new frontier in genomics

First human pangenome expected to better reflect human genomic diversity

NEW DELHI Researchers have released a draft of the first human pangenome – a new, usable reference for genomics that combines the genetic material of 47 individuals from different ancestral backgrounds to allow for a deeper, more accurate understanding of worldwide genomic diversity. The pangenome was produced by the Human Pangenome Reference Consortium (HPRC), a government-funded collaboration between more than a dozen research institutions in the United States and Europe, launched in 2019. By adding 119 million bases – “letters” in DNA sequences – to the existing genomics reference, the pangenome represents human genetic diversity not possible with a single reference genome. The researchers from the Rockefeller University, US, involved in the project called the single reference genome a “flawed tool”. One of its biggest problems, they said, was that about 70 per cent of its data came from a single man of predominantly African-European backg

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