Paul is being challenged by former Kentucky state legislator Charles Booker in the 2022 election.
Several social media users hailed Toon as a "hero" for her comment.
One said: "Haha Sen. Rand Paul was doing a virtual town hall and someone called in to tell him to "Get F**ked!" My hero!"
Another wrote: "How can I send a thank you card to the wonderful woman from KY who called into POS Rand Paul's live town hall meeting just to tell him to GET FKED? She's my hero today."
A third said: "This Kentuckian telling Rand Paul to "get f**ked" in a virtual town hall meeting is the best thing you will see on Twitter today."