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Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

Related Keywords

Kateryna Kon , ,Tarun Sai ,Tarun Sai Lomtemay ,Cancer ,Pancreatic Cancer ,Adenine ,Adenocarcinoma ,Adenosine ,Amino Acid ,Capillaries ,Fell ,Cell Line ,Fibroblast ,Gene ,Genes ,Glucose ,Glycolysis ,Ntracellular ,Alignant ,Metabolism ,Metabolite ,Etabolites ,Nutrients ,Oxygen ,Protein ,Humor ,

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