Radiation-Resistant Cancer Cells Can Be Killed Using Drug That Coaxes Persistent p53 Signaling
February 17, 2021
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All tissues are not equally sensitive to radiation. It has long been recognized that the well-known tumor suppressor protein and transcription factor p53 is linked to the degree of a tissue’s sensitivity to radiation. Yet how p53 regulates vulnerability to radiation has been elusive so far.
In an article titled “
Nature Communications, scientists at the Blavatnik Institute at Harvard Medical School, Massachusetts General Hospital, and the Novartis Institutes for BioMedical Research clarify that it is not the abundance of p53 protein in a tissue’s that correlates with the tissues’ sensitivity to radiation but the dynamics of p53 signaling following radiation.