INDIA New England News
New York– US researchers have found that an oral drug can be effective in stopping tumours from growing.
The team from the University of Colorado Cancer Center found that slowing down NLRP3 can reduce inflammation and curb tumour growth and progression.
“NLRP3 is a member of a larger family that is involved in sensing danger signals,” said Carlo Marchetti, from the varsity’s School of Medicine.
“It is a receptor that surveils the intercellular compartment of a cell, looking for danger molecules or pathogens.
“When NLRP3 recognises these signals, it leads to the activation of caspase-1, a protein involved in the processing and maturation of interleukin-1-beta into its biological active form, causing an intense inflammatory response. We found that in melanoma, this process is dysregulated, resulting in tumour growth,” Marchetti said.
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