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Intriguing new twist to unfolding story of DNA
Scientists have developed ground-breaking techniques for visualising the stresses and strains placed on tiny twisted DNA circles.
Using advanced atomic force microscope technology and a supercomputer, the research team from the Universities of Leeds, Sheffield, York and the John Innes Centre revealed that twisted DNA can develop kinks and creases that help to package it into compact shapes.
Getting a DNA molecule into a cell involves a process of folding called supercoiling, where the DNA is twisted and looped.
The researchers believe their technique for visualising how DNA can compact so tightly will accelerate the development of new forms of gene therapy where diseases can be prevented or cured by because these very small circles of DNA can squeeze into cells more easily.