Transcripts For DW In Good Shape 20240713

I cant go doesnt even recognize himself in the mirror he has a rare genetic mutation which is associated with early onset alzheimers disease. Who you laughing with now what are you laughing at. I dont know who is joking with. You get on with this i began noticing it when he was about 45 now hes got alzheimers disease just like his father did. He cried when he got the diagnosis. Was right on the field by cardoza brothers have come over for lunch the outside of his mutation has been passed down through his family for generations you know his father died of it 2 of his brothers and one sister have also been affected they all developed the condition and usually around 40 i cut os other siblings are currently healthy but theres a 50 percent chance they too have inherited the gene mutation and they also know that anyone with it seems to invariably develop alzheimers. To be honest if we dont get it it will be like winning the lottery. Alzheimers disease today the condition has a name but for generations people here talked of a debilitating curse because so many families were affected word of a cluster of people falling prey to memory loss in bel mira and the surrounding villages made its way to francisco look hair at a university in 19 it is. That 1st we were just curious we didnt know what to make of it all but one thing was clear to us that this was very significant. Paris team set to work combing through death certificates going back centuries talking to local priest some Family Members they were stunned by what they found is that this one had it this one died of it this one didnt this one did. They found that in a handful of villages over 25 extended families comprising over a 1000 people who are carrying the genetic mutation that leads to out simers a distressing find but a unique opportunity for the 1st time the doctors can work with Healthy People who they know are likely to develop alzheimers nowhere else in the world is there such a concentration of cases perfect conditions for studying the disease and maybe even finding a way of preventing it well. We might be successful or we might fail either way both outcomes would be very interesting from a scientific point of view. If we are but if we succeeded with that we could be on the road to finding an answer to alzheimers. Scientists believe the protein deposits build up between nerve cells in the brain eventually causing the cells to die they want to know whether these deposits can be impeded or even cleared. They are microscopic but the damage they cause is all too visible here we have a healthy brain and it is easy to brain. So. You can see the difference quite clearly the disease brain weighs 600 grams the healthy one weighs about twice that you can see at a glance what has happened to the patient. You know if we turn it over once again you can see the difference here we see a cavity has developed while here its all compact. But. Back to back and i was driving. The medical team regularly visits the affected families who are keen to support the research to help fight the disease any progress will come too late for a card but it could help his son or even his grandchild whos due to be born soon. I dont want to think about it our child will be healthy with gods help. There is currently no cure for out science this study in columbia has raised hopes of a breakthrough thats not happened yet but the marrying team is still working on it i mean. Id like to be there when that happens just for the familys sake but it could also lead to further studies into curing or preventing this disease thats the goal. But id love to be part of it if thats possible lets hope so. So then we went. Up if those hopes are realized the project could help tip the scales in the fight against alzheimers. As weve seen alzheimers not only affects patients but their families as well how to care for patients and their families this is what im going to talk about. From the journey Alzheimer Society and im going to be turnout. Elemis was the ultimate disease is also called a family disease why is that. People with the mentor more and more help when the mentor progresses and the Family Members organize every day life they make appointments with the doctor. They care for activities they care for care for financial matters and many more things. At the same time maybe they go to work maybe they have own families with little children so. They need lots of commitment and they dont have really much time for themselves and so they are under high social pressure physical psychological pressure yeah so you see a lot of affected people so so whats the main problem. Relatives have problems in dealing with the changing behavior off the pace. Because this happens when the mentor progresses right so when you feel some memory loss theres a big question is it just in my old forgetfulness always it also has to cease. It all seemed quite harmless at 1st dabble village golf began to experience memory problems a little later she was diagnosed with early stage alzheimers im from in the beginning i was often very sad and down but then i realised well it has to happen at some point and life has to go on you cant change that it is what it is. That was 18 months ago the 70 year old cant always find the right words or remember what she wants to buy when shes out shopping but fine and large she still manages to get by. Sometimes i have problems with my friends for example or forgetting things that happen sometimes. But nothing really bad i dont forget to turn off the tap or anything like that. So touch wood i havent done anything serious yet. But babble builds doff knows that things wont stay like this she used to be a nurse and later manage a retirement home so she knows that her memory problems will increase. But no one can say how quickly the disease will progress and how severe it will become. I said i dont know what things will be like by the end of the year id like to visit the baltic on holiday you know and maybe somewhere else but i definitely want to do that. And ill do that sooner rather than later. Today shes meeting susana sachs old from the german Alzheimers Society recently beveled build off got involved with the organization it gives her the opportunity to compare her experiences with those of other people with the disease to have a boost off likes to stay active. The german Alzheimers Society works to improve the lives of people with dementia the Organization Helps the patients themselves and their families. Weve put together Information Online if someone gets to mention before the age of 65 it can be especially difficult for the family if children are still at home yeah. Its important that people make provision for the time when they can no longer cope alone that will build stoff has already done that. At this point i made a plan with a friend who ive known for a very very long time i Work Together with him in the hospital. Hes the boss there now if something happens to me hell see to it that i get up. Place in a nursing home before that its good to have Something Like that and that. There is no cure for alzheimers patients and their families have to adapt to the disease as best they can one of the worst things is not knowing when your condition might suddenly deterioration. I think everyone fears that thats why its important to make the most of each day. That. Shouldnt be so thats pointless. And you need to meet up with other people and. Thats another reason that you got involved with the Alzheimers Society Beverly Hills store hopes to meet new people to go out and do things with. It ive always liked to dance but 1st you have to find someone to go with and i dont have a partner even if you have a nice bunch of friends none of them go dancing with me. So if you happen to come to berlin id like to dance with probably this stuff feel free to contact us we heard a lot about the german Alzheimers Society so what actually do you do in this association how do we help patients and families we are selfhelp organization and as the German Society we are the federal aviation off 230 out some associations in germany and to gather our main aim is to improve the life and the life quality of persons with dementia and their families and what is your advice if a patient would phone you or would contradict you. It depends on the situation he or she is in at this moment so. People that are calling us are mostly the relatives and they ask for help because. Behavior off persons with dementia is changing. When he or she has a dementia and this causes lots off conflicts so you giving advice to both to patients and the family of course right and its not always alzheimers patients losing his memory its the other forms of dementia so so you do advice in this direction as well yes we do when someone notices the symptoms of maybe dimentia. Memory problems for example we. Were advised to go to the doctor because just the medical examination can provide clarity at this moment but i mean time is disease is life changing when for both for the patient and for the family so what kind of values can you really give a family liked to adept with a situation in which we are. Yet to adapt with this situation to talk about the situation and to think about the future because dementia progresses. So one of the main problems in everyday life is that really like financial matters so much driving license oh. Yeah most problems are caused by the changing behaviors so some persons with the mention sometimes get angry or loud or they still want to drive even though this isnt possible anymore some have the feeling of being dropped and accuse their relatives and handling those mistrust is really hard its a heavy task so if the disease is not curable right now and its very hard to treat anyway so one of your advise you confused try to adapt to the next situation but is it really possible to adapt to this kind of serious illness yes it is by that is a process this process took a lot of time and. The Family Members. Have to inform themselves about the dementia when i know dementia or memory problems are part of dementia than i can better understand that my husband does not know anymore where we went for holidays 2 months ago and then i i dont take this personal and react less emotional maybe but it is hard it stays hard and there will be days where my patience breaks because im going to be asked the same thing 10 times in 5 minutes not long ago there was hope on the horizon for alzheimers patients there was a drug which was a little antibody but the studies were stopped. We sent our chief reporter peter to find out what is new in the treatment of all sides. Here at the lights exude the apes are a source of fascination for visitors. Perhaps its because our primate relatives are so similar to us. They laugh they play games and express affection much like we do. They also get many of the same illnesses like colds diabetes and even depression but one condition they dont get is out timers. Why is that did something go wrong in the evolution of the human brain. Neurologist thomas our hand heads the power flexes institute of Brain Research in my pick he spent the last 40 years studying out simers does it use. This host. You might have a certain genetic disposition which makes it more likely that youll develop alzheimers. But it seems that even then the onus only develops if on top of this predisposition other factors come into play such as environmental influences and possibly stress. Theres a rise a bit in this place for. As the human brain develops certain areas became particularly pronounced this led to new abilities that are unique to human beings. Language is one of them. Another is our selfawareness our sense of our own existence. And our ability to process memory is its precisely these abilities that are affected by alzheimers memory is the 1st to go followed by language then the individual selfawareness changes and in the end is lost completely. With numerous possible explanations for. This phenomenon have been proposed its often seemed that a potential treatment was within reach but to this day theres been no decisive breakthrough. As there is. One of the reasons for that is that we dont up sufficient understanding of the functions that are affected by alzheimers such as language of memory and selfawareness even in the brains of healthy individuals. Once you realize that you can appreciate how difficult it is to find out why such processes are being disrupted. When you dont fully understand how they work normally. And. Studies have focused in particular on 2 protein deposits in the brain beta amyloid plaques and neuro fiber larry tangles made up of protein called tau. Both occur naturally in the body but in alzheimers patients they disrupt the communication between the nerve cells causing them to die that was long thought to be the cause of the condition but its quite possible that these plaques are merely a side effect or a consequence of alzheimers plaids so the challenge remains to find the root causes of alzheimers i would not assume that the amyloid deposits of the calls. The scientists at the power flexi chanson should study tissue samples and neurons theyre particularly interested in 2 questions what regulates the lifecycle of nerve cells in the brain and what might interfere with it and what roles do genes play the researchers found that ultimately patients exhibit increased numbers of neurons with genetic abnormalities but is that a cause or an effect of the disease its still unclear. Thomas arent believes that some people are born with a predisposition for us timers what is certain is that changes occur in the brain 20 or 30 years before the. Symptoms of alzheimers appear in some cases perhaps even earlier. This leads to the question of whether the disease could be arrested at this early stage but how do you detect affected people if they dont display any symptoms. Doesnt these are going to be your model for this is where you turn to biomarkers. This is an area of research that seeks to find biomarkers that can help you to identify patients that are particularly at risk of developing this disease. His team came up with a blood test for rapid diagnosis which is being developed by a group of Biotech Companies it focuses on the early phase of alzheimers before cognitive symptoms appear scientists believe thats where the key to the disease and to potential treatments lies. Realistically i have to assume that on the basis of what we know right now we would have to wait at least another generation maybe 30 or 40 years before we have a really effective treatment that addresses the causes of the disease if indeed thats even possible. Under doubts about. Hops well never be able to intervene in the process of alzheimers disease the way that we would like to. Sort of initial. What really happens in nerve cells in the brain what role is claimed by genetic variations and environmental factors these things need to be better understood perhaps then well know why were so different from our closest animal relatives when it comes to timers. No adequate therapy for the next 30 to 50 years so its very important that we take care of all alzheimers patient and there are lessons today to make their lives a little bit easier and youre trying to do this for example with discussion groups where did this because Family Members get to know their other Family Members that experience the same things in their day to day life. And they learn that they arent alone with this disease and they. They get tips and hints from the other families and yeah i hear how they try to deal with some conflicts in everyday life you have a lot of conflicts in the families with the patients and the relatives like aggressive behavior so how do you cope with it. Aggressive behavior is caused by. The fact that persons with the mentor assess a situation differently than their Family Members and they insist on their opinion when the Family Members also insist that different opinion then we have those conflicts and the relatives are the only one that can change those situations so that they can try to react patiently they can try to take the fear persons with the mention feel seriously and yeah maybe calm down the situation yes especially in the beginning of the disease just a lot of fear anger and grief so how can you cope with all the dimensions. 1st of all of the listen. Try to find out what in this situation is really. Makes clear the person with dementia or the Family Member and so we also can try to find out what could be relieving which could be helpful at that moment i mean its a very special disease alzheimers disease its a very emotional disease so many of the caregivers simply burned out. Giving care so how can you prevent a brain know. With help and support and with help and support from the beginning of the disease on. Because so we can somehow counteract the overwork or the only onus off the caregivers at some point it may not be possible to keep the outside as patient inside the family so you have to give them away to a nursing home to professional caregivers and this is a big huge step because address is not a conflict so so whats your advice to. The families dont make this decision easily easily they make it when theres no alternative anymore then their conflict stays of course and again. It helps to go to a Selfhelp Group to exchange with other. Relatives or to use a Counseling Service or Something Like that which you like to know if you later in your life will get alzheimers disease no i dont want to know it because theres no theres no adequate therapy right now i dont want to know if im going to get dementia and i do understand this. If youve got any questions you like me to ask oh experts be sure to watch meaning theyre. In good shape shell weiqi help share one g. W. That covers many aspects of health can we. Whats new in medical treatment nutrition fitness and beauty we just does these topics in depth with specialists and offer you opportunities to pose your own questions so get in touch. Many people are afraid if they have relatives with alzheimers disease they will get all timers themselves so what do you suggest. It is important to know that. Most of the. Diseases are not caused by genetic reasons. The 08 s the highest risk factor. You could say and if you want to do something. Guarding. It is important to yeah to have adequate exercise a balanced diet to stay active socially. To treat knowing diseases like treasure are Something Like that thank you so much for this very interesting talk on this very difficult matter. And thats it for today see you next week and until then lets all try to stay in good shape. With. The uniform im still. Offering all 3. Drama. Inside her care. Thats part of the future and i think that the small saleh has Great Potential for. A small state that house all lot to offer. Chicken. D. W. To live on stage. With well sung and the radio Quiet Creative biographical well. Ringback done using the great reformers own texts and music by Johann Sebastian bach. Dancing with the gaunts no heaven without help. In 60 minutes will you. Now to. The Sustainable Way discover the bow she. Starts made on w. The freedom of the press during the corona crisis of. The pandemic has changed the world was taking place and worsen the situation for many journalists across the globe. But especially in these times of crisis unbiased information is essential goods because of the shock the dumbest of the deeds World Press Freedom day w. P m. This is star land estate in southwestern germany that borders france at luxembourg excluding the city states of berlin braman and hamburg solid is the smallest state in germany roughly 100 kilometers from end