According to Monday's report, 246 of the new cases are confirmed and 21 are probable.
State health officials say there are 6,523 active cases in the state, a decrease of 172 since Sunday.
The state's health department has reported no additional virus-related deaths, keeping the state's death toll to 1,446.
State data shows 439 more residents have recovered from the virus, bringing the state's total recoveries to 89,688.
Currently, 288 residents in the state are hospitalized due to the virus, which is up from 274. Since the beginning of the pandemic, there have been 5,583 COVID-19 hospitalizations in South Dakota.
Health department data shows 9,875 Pfizer vaccines and 4,924 Moderna vaccines have been administered throughout the state.