This study focuses on the relationship between the COVID-19 pandemic and criminal activity in Mexico. It looks at data over twenty-four months prior to and during the public health crisis. The study examines both national-level and state-by-state COVID-19 infection rates data and their relationship to four types of crime—two closely related to organized crime in the general literature, homicide and vehicle theft, and two more conventional criminal activities, muggings and domestic violence. Regarding time, it examines four different time periods—two six-month periods before and two six-month periods during the pandemic to enable comparisons by type of crime at the national level, at the individual state level, and over time. The COVID-19 infection rate appears to have had practically no influence on any of the four types of criminal activity examined in the study. Even so, different crimes did respond differently over time. At the national level, homicide rates stayed at the same levels throughout. Domestic violence rates were lower in the first period but increased in the second period analyzed. Muggings and vehicle, however, theft rates were down for both periods of analysis. The results of the study at the subnational or state level, however, show much more variation, with some states showing higher or lower level of crime depending on the type of crime, the individual state, and the period. The general conclusion is that COVID-19 seems to have had little impact on the country’s criminal landscape and other variables may explain the variation observed at the state level.